While not as well-known as stars who appear in front of the camera, producer Vachon has played an important role in independent cinema for decades. She produced films by Todd Haynes, Todd Solondz, and Paul Schrader, among many others. In 1996, Vachon and Pamela Koffler founded Killer Films, an important company for independent cinema. Its films include Kids, Boys Don't Cry, and I’m Not There.